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About Cardiovascular Disease

Cardiovascular Disease

A Crisis in Plain Sight

Cardiovascular disease (CVD) is the #1 cause of death in the U.S., responsible for nearly 1 in 3 deaths. Despite advancements in care, research, and prevention, CVD continues to outpace all other chronic diseases. CVD is not one condition; it's a family of diseases that affect the heart and blood vessels. This includes:

  • Coronary heart disease (CHD)
  • Heart attacks (myocardial infarction)
  • Stroke
  • Heart failure
  • Peripheral artery disease

About Coronary Heart Disease

CHD often develops silently over many years, and its first symptom may be a heart attack.

#2

cause of hospitalization and adds $13,000 more per year to patient healthcare costs,

1 in 20

U.S. adults aged over 20 years live with coronary heart disease

3-4 million

Americans are affected by Ischemia with No Obstructive Coronary Arteries (INOCA), a subset of CHD

About Heart Attacks

Heart attacks don't always announce themselves. Many occur without chest pain, especially in women and people with diabetes.

40 seconds

is how often someone in the U.S. experiences a heart attack

1 in 5

heart attacks are silent, occurring without warning

800,000+

is the number of heart attacks occurring annually

Current Tools Can Leave Gaps in Cardiovascular Care

Traditional risk models (e.g., age, cholesterol, blood pressure) offer one-size-fits-all guidance, while tools like CT scans and stress tests detect disease after symptoms appear. But both often miss the early, complex stages of coronary heart disease.

Early Detection

Individuals at high risk may not be identified early enough

Undetected

Others with active, asymptomatic disease may go undetected

High Risk

Some patients may be labeled high-risk without underlying disease

Intervening

Opportunities to intervene, before symptoms or events occur, can be missed

Our Tests Analyze Epigenetic and Genetic Biomarkers Reflective of Inherited Predisposition and Acquired Factors from Lifestyle and Environment

Explore Our Solutions
  1. Centers for Disease Control and Prevention. "Heart Disease Facts." Centers for Disease Control and Prevention. Accessed September 2, 2025. https://www.cdc.gov/heart-disease/data-research/facts-stats/index.html
  2. Haidar, A., et al. "National Costs for Cardiovascular-Related Hospitalizations and Inpatient Procedures in the United States, 2016–2021." American Journal of Cardiology 234 (2024): 63–70. https://doi.org/10.1016/j.amjcard.2024.10.003
  3. Kazi, D. S., M. S. V. Elkind, A. Deutsch, et al. "Forecasting the Economic Burden of Cardiovascular Disease and Stroke in the United States Through 2050." Circulation 150, no. 4 (2024): e89–e101. https://doi.org/10.1161/CIR.0000000000001258
  4. Tsao, C. W., A. W. Aday, Z. I. Almarzooq, et al. "Heart Disease and Stroke Statistics—2023 Update." Circulation 147 (2023): e93–e621. https://doi.org/10.1161/CIR.0000000000001123
  5. Polyak, A., J. Wei, M. Gulati, and N. Bairey Merz. "Clinical Aspects of Ischemia With No Obstructive Coronary Artery Disease (INOCA)." American Heart Journal Plus 37 (2024): 100352. https://doi.org/10.1016/j.ahjo.2023.100352

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