The First Sign of Heart Disease Should Not Be a Heart Attack
We examine your unique biology as a category of one to reveal insights that traditional methods may miss.
Coronary Heart Disease and Heart Attacks Often Strike Silently
800,000+
Americans have a heart attack
each year
40 seconds
is how often someone in the U.S. experiences a heart attack
1 in 5
heart attacks are silent, occuring without warning
Coronary Heart Disease and Heart Attacks
Coronary heart disease (CHD) is the leading cause of death in the U.S., responsible for nearly 1 in every 3 deaths. Each year, more than 800,000 Americans experience a heart attack, and for many, it is the first sign of underlying disease.
While CHD generally results from a build up of plaque in the arteries of the heart, CHD and heart attacks can also occur when the arteries are not severely blocked. One example is Ischemia with No Obstructive Coronary Arteries (INOCA). INOCA is particularly common in women and happens when blood flow to the heart is reduced without major plaque build up or visible blockages.
Plaque build-up and the presence of traditional risk factors like high blood pressure, diabetes, or high cholesterol are important to know, but they don’t fully capture heart disease.
Learn More About CHD
Risk Factors and Conventional Tests Don’t Tell the Whole Story
61%
of those who experience a coronary heart disease event were previously deemed low risk by standard assessments
50%
of those with CHD do not have traditional risk factors
Up to 1/3
of coronary artery disease are missed by tests like stress EKG, SPECT and stress echo
Your DNA Holds Clues to Your Heart Health
Your DNA is your genetic blueprint, the code you are born with. But genetics accounts for less than 20% of heart disease risk.
The larger influence comes from epigenetics, which is how your environment, lifestyle, and everyday experiences affect how your genes are expressed. Epigenetics acts like the switchboard that controls whether certain genes linked to heart disease are turned on or off.
That means your heart disease risk isn’t fixed at birth. It shifts and changes over time, depending on both your genetics and the world around you.
By combining genetics and epigenetics with artificial intelligence, our tests deliver a more complete and precise view of your heart health than traditional methods alone.
Our TechnologyYour Cardiovascular Care Should be Guided by Your Unique Biology
Rx Only FSA/HSA Eligible
A blood test that predicts your three-year risk of a coronary heart disease event, including a heart attack
Rx Only FSA/HSA Eligible
A blood test that can detect the presence of coronary heart disease and help inform personalized treatment
What Makes Our Tests Different
By combining epigenetics with AI, our tests go beyond traditional tests to measure your unique molecular biology.
Non-Invasive
Our blood tests do not require fasting or exposure to radiation that could increase cancer risk.
Cutting-Edge
Our technology combines epigenetics, genetics, and AI to more comprehensively assess heart health even in the absence of risk factors.
Evidence-Based
Our tests are clinically validated, backed by peer-reviewed publications, and have high sensitivity and specificity.
Accessible
Samples can be collected via phlebotomy in a clinical setting or patients can request a test virtually and collect their sample at home.
Our Testing Process
Request a Test
Our tests must be prescribed by a licensed healthcare provider. Request your at-home test through our independent telemedicine partner.
Request a Test
Blood Draw
Blood Draw
After a healthcare provider orders the test, you’ll receive an at-home kit with materials to collect and ship your sample.
Test Results
Test Results
Results will be ready within 10 business days of your sample arriving at our lab. The healthcare provider will share results and is available for a follow up consultation.
The Best Time to Act is Before
It’s Too Late
Frequently Asked Questions
Epi+Gen CHD™ is a risk assessment test that identifies your likelihood of experiencing a coronary heart disease event, including a heart attack in the next three years. This test is intended for those who do not currently have signs or symptoms indicative of heart disease. Epi+Gen CHD™ is not intended for those who've had a heart attack or cardiac operation or experienced chest pain (especially with exertion) and those who have had a bone marrow transplant.
PrecisionCHD™ is a diagnostic test, meaning it's meant to help identify those who have coronary heart disease. If you have signs and symptoms indicative of heart disease or have been previously identified as being at high risk of developing heart disease, PrecisionCHD™ may be right for you. PrecisionCHD™ is not intended for those who have had a bone marrow transplant.
Ultimately, a licensed healthcare provider will determine if the test you requested is right for you based on all available information including your medical history, presence of risk factors and any signs or symptoms.
- Heart Disease Facts. CDC. Accessed September 2, 2025. cdc.gov/heart-disease/facts-stats
- Dogan MV, Knight S, Dogan TK, Knowlton KU, Philibert R. External validation of integrated genetic-epigenetic biomarkers for predicting incident coronary heart disease. Epigenomics. 2021;13(14):1137-1152.https://doi.org/10.2217/epi-2021-0123
- Cardio Diagnostics, Inc. Internal Claims Data Analysis.
- Takx RAP, Blomberg BA, El Aidi H, et al. Diagnostic Accuracy of Stress Myocardial Perfusion Imaging Compared to Invasive Coronary Angiography With Fractional Flow Reserve Meta-Analysis. J Clin Med. 2024;14(17):6238.https://doi.org/10.3390/jcm14176238
- Hou K, Burch KS, Majumdar A, et al. Accurate estimation of SNP-heritability from biobank-scale data. Nat Genet. 2019;51(8):1244-1251. doi:10.1038/s41588-019-0465-0